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Growth-limiting intracellular metabolites in yeast growing under diverse nutrient limitations

Microbes tailor their growth rate to nutrient availability. Here, we measured, using liquid chromatography-mass spectrometry, textgreater100 intracellular metabolites in steady-state cultures of Saccharomyces cerevisiae growing at five different …

Coordinated concentration changes of transcripts and metabolites in Saccharomyces cerevisiae

Metabolite concentrations can regulate gene expression, which can in turn regulate metabolic activity. The extent to which functionally related transcripts and metabolites show similar patterns of concentration changes, however, remains …